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Neuromuscular toxicity and rhabdomyolysis have been reported from chronic treatment with colchicine in therapeutic doses, especially in combination with other drugs known to cause this effect.
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In 2009, after winning fda approval, url pharma won exclusive rights to sell colchicine as a treatment for acute gout for three years, and seven-year exclusivity to sell it for familial mediterranean fever, under the orphan drugs act.
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for children it hasn t been established that colchicine is safe and effective in the treatment of gout in children.