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Withdrawal symptoms occur frequently upon paroxetine discontinuation and sometimes are very severe.

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Inhibition of cyp2d6 by paroxetine may lead to reduced plasma concentrations of an active metabolite endoxifen and hence reduced efficacy of tamoxifen see precautions .

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Under these conditions, the chromatogram sample serum free of paroxetine shows a wide front to 4 min , but no other peak was observed at higher elution times fig.

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